PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
September 19, 2025Alzheimer s & DementiaOpen Access

Objective physical activity and Alzheimer's disease burden in the population‐based Rotterdam Study

View Full Paper
Ask AI
Bookmark
Share

Authors

PHPhuong Thuy Nguyen HoMVMeike W. VernooijTVTrudy Voortman

Discussion

Loading...

Member takes

Overview

Observational analysis finds no relationship between physical activity and Alzheimer’s disease biomarkers, suggesting other pathways.

Key Points

  • Physical activity showed no significant association with Alzheimer's disease biomarkers after 7 years.
  • Plasma beta-amyloid (Aβ)42/Aβ40 and p-tau217 levels were unaffected by physical activity levels.
  • The method included accelerometer measurements and PET imaging to evaluate brain Aβ burden.
  • These findings suggest that physical activity's influence on dementia risk may operate through different mechanisms.

Cite This Study

Ho et al. (2025) studied this question.

synapsesocial.com/papers/68d464f831b076d99fa648cbhttps://doi.org/10.1002/alz.70655
View Full Paper
Ask AI
Bookmark
Share