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September 19, 2025CellsOpen Access

NUP214 in Acute Myeloid Leukemia

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This review explores the role of nup214 translocations in acute myeloid leukemia, highlighting their potential prognostic impact.

NUP214 fusion proteins are implicated in leukemic transformation in acute myeloid leukemia.
The t(6;9) translocation encoding DEK-NUP214 occurs in 1–2% of AML patients, with adverse prognosis improved by stem cell transplantation.
SET-NUP214 fusion variants, though less common, share biological similarities with DEK-NUP214 but lack clear prognostic data.
Other NUP214 fusions, like NUP214-ABL1 and NUP214-SQSTM1, are rare, with limited case reports detailed.

Bruserud et al. (2025) studied this question.

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September 19, 2025CellsOpen Access

View Full Paper

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Authors

This review explores the role of nup214 translocations in acute myeloid leukemia, highlighting their potential prognostic impact.

NUP214 fusion proteins are implicated in leukemic transformation in acute myeloid leukemia.
The t(6;9) translocation encoding DEK-NUP214 occurs in 1–2% of AML patients, with adverse prognosis improved by stem cell transplantation.
SET-NUP214 fusion variants, though less common, share biological similarities with DEK-NUP214 but lack clear prognostic data.
Other NUP214 fusions, like NUP214-ABL1 and NUP214-SQSTM1, are rare, with limited case reports detailed.

Bruserud et al. (2025) studied this question.

View Full Paper

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