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September 19, 2025Journal of Medicinal Chemistry

Light-Driven ESIPT-Based Anthraquinone Analogues for Synergistic Fluorescent Self-Reporting and Photodynamic Therapy of Malignant Tumors

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Authors

JHJiao‐Na HanMYMeng YangYHYao He

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Overview

Development of anthraquinone-based photosensitizers improves tumor targeting and fluorescence, indicating enhanced therapeutic efficacy.

Key Points

  • Tumor growth was significantly inhibited by the compound 1H-D1, leading to an impressive reduction ratio of approximately 0.24.
  • A dual-effect synergy was observed as monomer products restored fluorescence and generated reactive oxygen species under light irradiation.
  • The approach utilized polymerization and end-group modifications to develop photosensitizers specifically targeting mitochondria.
  • The findings suggest that enhancing fluorescence during therapy can provide valuable feedback for treatment outcomes.

Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/68d466be31b076d99fa65a5ehttps://doi.org/10.1021/acs.jmedchem.5c02158
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