Thiosquaramides: Dual-Function Ionophores for Zn²⁺ and Cl⁻ with Ion Dependent Anti-Microbial Activity

Q: What type of study is this?

This is a Experimental Study study.

Robert B. P. Elmes; Xiaoxia Luo; Luke Edward Brennan; Chris S. Hawes; Tobias Kraemer; John P. Farragher; Shane Robinson; Kevin Kavanagh

doi:10.1039/d5ob01166c

January 1, 2025Organic & Biomolecular ChemistryOpen Access

Thiosquaramides: Dual-Function Ionophores for Zn²⁺ and Cl⁻ with Ion Dependent Anti-Microbial Activity

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Key Points

Thiosquaramides exhibit dual-function ion transport, impacting Zn²⁺ and Cl⁻ levels in cells.
Analysis shows that these ionophores possess unique anti-microbial activity linked to ion transport.
These findings point to potential therapeutic applications in modulating cellular ion dynamics.
The study supports the development of synthetic transporters to manipulate ion homeostasis for medical purposes.

Implication

This research reveals how thiosquaramides transport Zn²⁺ and Cl⁻ ions in cells, indicating their anti-microbial potential.

Abstract

Synthetic transmembrane transporters have garnered considerable interest in medicinal chemistry for their ability to modulate cellular processes via ion transport. These ionophores can disrupt intracellular ion homeostasis, often triggering biological...

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Cite This Study

Elmes et al. (2025) studied this question.

synapsesocial.com/papers/68d469c831b076d99fa66826 https://doi.org/10.1039/d5ob01166c

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Thiosquaramides: Dual-Function Ionophores for Zn²⁺ and Cl⁻ with Ion Dependent Anti-Microbial Activity

Key Points

Implication

Abstract

Discussion

Cite This Study

Thiosquaramides: Dual-Function Ionophores for Zn²⁺ and Cl⁻ with Ion Dependent Anti-Microbial Activity

Key Points

Implication

Abstract

Discussion

Cite This Study

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