The Effect of Massage and Biochemical Oxidative Stress Determinants in Hemodialysis Patients with Restless Leg Syndrome in Turkish People

There is limited information about the etiological factors, treatment methods, and the relationship between oxidative stress and antioxidants of restless legs syndrome (RLS) in patients with chronic kidney disease (CKD). This continues to be a significant problem in patients with RLS and CKD. Therefore, it may be useful to target the hypothesis that 'RLS disease may be associated with underlying inflammation and the oxidative stress it creates'. To evaluate the effect of massage and the relationship between biochemical oxidative stress markers and the disease in hemodialysis patients with restless legs syndrome. Eligible patients with CKD stage 4 (CKD 4), pre-dialysis stage 5 (CKD-5ND) and hemodialysis-dependent stage 5 (CKD-5D) patients were enrolled from local dialysis units and kidney clinics. The International RLS Study Group rating scale was used to diagnose RLS and measure its severity. Blood samples were taken before and after treatment and the levels of some oxidative stress and antioxidant parameters were examined. In the intra-group comparison of experimental and control; In the experimental group, after the massage, RLS, TAC and TOC values ​​decreased significantly compared to before the massage, while NO and PON values ​​increased significantly.