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A tandem synthesis approach generates tertiary alcohols from difluoroenoxysilanes and silyl-α-ketoalkynes, suggesting efficiency with CuCl.
A one-pot tandem aldol/desilylation/CuAAC sequence is developed, allowing facile synthesis of tertiary alcohols featuring an α-difluoroketone moiety and a 1,2,3-triazole at the α position in moderate to good yields, with an operationally friendly manner. While Bi(OTf)3 was the optimal catalyst for the Mukaiyama-aldol reaction of silyl-α-ketoalkynes and difluoroenoxysilanes, CuCl was found to efficiently mediate the alkyne-azide cycloaddition.
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Liu et al. (2025) studied this question.
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