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September 20, 2025Neuropathology

Coexistence of IDH1 Mutation and KIAA1549::BRAF Fusion in a Diffuse Glioma: A Case Report With Clinical, Radiological, and Pathological Correlation

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Authors

SDSumanta DasSASunita AhlawatSNShrinidhi Nathany

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Overview

Case report reveals dual occurrence of IDH mutations and KIAA1549::BRAF fusion, suggesting implications for glioma treatment.

Key Points

  • The case presents a diffuse astrocytoma exhibiting co-occurrence of IDH1 mutation and KIAA1549::BRAF fusion, challenging previous beliefs.
  • Histopathological analysis confirmed the presence of high mitotic activity, endothelial proliferation, and necrosis alongside genetic alterations.
  • Molecular profiling detected IDH1 mutation and KIAA1549::BRAF fusion, indicating the need for comprehensive diagnostics in glioma cases.
  • The findings suggest that multimodal therapeutic approaches are necessary to target both the IDH mutation and KIAA1549::BRAF fusion pathways.

Cite This Study

Das et al. (2025) studied this question.

synapsesocial.com/papers/68d46abb31b076d99fa67e10https://doi.org/10.1111/neup.70027
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