Diverting Loop Ileostomy as an Alternative to Emergent Colectomy in Acute Severe Ulcerative Colitis Flare following Checkpoint-Inhibitor Therapy

Lay Summary Our case shows that a diverting ileostomy may be a viable bowel-sparing surgical option instead of colectomy during a refractory ulcerative colitis (UC) flare from checkpoint-inhibitor therapy, allowing time for checkpoint-inhibitor washout and optimization of biologic therapy prior to ileostomy reversal.