Methionine-Facilitated Chalcogenation of Peptides through Palladium-Catalyzed β-C(sp3)-H Activation

Q: What type of study is this?

This is a Experimental Study study.

Jian Tang; Qi Lu; Fengjie Lu; Yi Sun; Yuqi Pan; Wei Qu

doi:10.1039/d5cc04285b

January 1, 2025Chemical Communications

Methionine-Facilitated Chalcogenation of Peptides through Palladium-Catalyzed β-C(sp3)-H Activation

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Key Points

The methodology enables efficient chalcogenation of peptides, enhancing the potential for functionalization.
Using methionine as a directing group facilitates site-specific modifications, expanding peptide chemistry.
Palladium-catalyzed β-C(sp3)-H activation provides a robust platform for synthesizing diverse peptide derivatives.
This approach highlights the versatility of metal-catalyzed strategies in peptide modification and design.

Implication

Novel methodology achieves site-selective chalcogenation in peptides, suggesting methionine's role as a directing group.

Abstract

We report a novel methodology for the site-selective chalcogenation of peptides via Pd-catalyzed β-C(sp3)-H activation. In this study, native methionine residues serve as an intrinsic directing group, while various diaryl...

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Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/68d46cb831b076d99fa687a5 https://doi.org/10.1039/d5cc04285b

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Methionine-Facilitated Chalcogenation of Peptides through Palladium-Catalyzed β-C(sp3)-H Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

Methionine-Facilitated Chalcogenation of Peptides through Palladium-Catalyzed β-C(sp3)-H Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

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