September 19, 2025Open Access

Protein tyrosine phosphatase receptor type D - A convergent risk gene for MDD, BPD, and ADHD and regulator of dopaminergic neuroplasticity in reward associated circuits; A multivariate GWAS, brain tissue and cell type enrichment, and gene finemapping

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Discussion

Multivariate genetic analysis reveals PTPRD’s role in dopamine neuron dysfunction, suggesting new therapeutic targets.

Significant genetic overlap observed across major depressive disorder, bipolar disorder, and attention-deficit hyperactivity disorder.
Enrichment analysis identified a candidate gene, protein tyrosine phosphatase receptor delta, in dopamine neurons.
Statistical frameworks reveal altered activation of signaling pathways affecting reward behaviors in PTPRD knockout models.
Integrated analysis presents mechanisms driving psychiatric comorbidity and potential targets for future research.

Lawrence et al. (2025) studied this question.

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