Cohort study analyzed revision risk for periprosthetic joint infection in total knee arthroplasty patients using antibiotic-loaded or plain cement, indicating similar outcomes.
Key Points
Revision risk for periprosthetic joint infection was similar between antibiotic-loaded and plain bone cement groups.
The cohort study analyzed 685,818 total knee arthroplasties from 11 registries, finding cumulative revision rates of ≤1.6%.
Statistical analyses included Cox regression for adjusted hazard rate ratios to compare outcomes of both cement types.
Further clinical trials are needed to confirm the efficacy of antibiotic-loaded cement in high-risk patients.