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September 21, 2025Cell Reports Medicine23 citationsOpen Access

Global, regional, and national burden of headache disorders, 1990–2021, with forecasts to 2050: A Global Burden of Disease study 2021

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TWTissa WijeratneJOJiyeon OhSKSoeun Kim

Key Points

  • In 2021, 2.0 billion people suffered from tension-type headaches, while 1.2 billion experienced migraines, markedly affecting quality of life.
  • Despite a stable age-standardized prevalence rate, the crude rates of headache disorders and years lived with disability have significantly increased.
  • Women aged 30-44 years bear a disproportionately higher burden of headache disorders, underlining disparities in healthcare access.
  • The findings call for urgent prioritization of headache disorders in global health strategies and increased funding for recognition.

Abstract

Headache disorders, especially migraines and tension-type headaches (TTHs), are major global public health concerns, as shown by the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. We provide updated global estimates of prevalence and years lived with disability (YLDs) from 1990 to 2021 across 204 countries and territories and forecasts through 2050. In 2021, there are 2.0 billion people with TTH and 1.2 billion with migraine. Although TTH is more prevalent, migraine causes higher disability. While crude prevalence and YLDs increased, age-standardized rates remained stable and are projected to continue this trend due to population growth. There is a disproportionately higher burden in women aged 30-44 and countries with higher Socio-demographic Index and Healthcare Access and Quality Index. Despite this, migraines remain underrecognized in health policies and funding. This study emphasizes the urgent need to prioritize headache disorders in global health agendas.

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Cite This Study

Wijeratne et al. (2025) studied this question.

synapsesocial.com/papers/68d46fd431b076d99fa6a24ahttps://doi.org/10.1016/j.xcrm.2025.102348
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