Wake-promoting therapy for prolonged disorders of consciousness: The central role of cerebral glucose metabolism

With the development of neuroscience, phased achievements have been made in the treatment of patients with prolonged disorders of consciousness(pDoC), but the bottleneck of uncertain clinical efficacy remains to be broken through. This review systematically expounds the core role of glucose metabolism in the wake-promoting mechanism, and for the first time positions glucose metabolism as a common pathway for awakening in pDoC, revealing its "mechanism explanation - efficacy prediction - treatment navigation" trinity value. It proposes that glucose metabolism is the energy cornerstone for consciousness recovery, and residual glucose metabolism leads to the localization of therapeutic targets. Completing the metabolic map can guide individualized intervention. Provide theoretical support for the future development of metabolism-oriented and metabolism-responsive neural regulation schemes.