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September 22, 2025Circulation37 citationsOpen Access

Post–Myocardial Infarction Psychological Distress: A Scientific Statement From the American Heart Association

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GLGlenn N. LevineRCRobert M. CarneyBCBeth E. Cohen

Key Points

  • Postmyocardial psychological distress impacts up to 50% of patients after myocardial infarction, increasing future cardiac events.
  • Psychological factors like depression, anxiety, and posttraumatic stress disorder can worsen health outcomes after myocardial infarction.
  • Improving psychological health through various interventions may lead to enhanced quality of life and better cardiac recovery.
  • Further studies are needed to evaluate treatment effectiveness for psychological distress's impact on cardiac prognosis.

Abstract

The importance of psychological distress in patients with cardiovascular disease is increasingly recognized as both a contributing factor to the development and progression of cardiovascular disease and a consequence of the development of cardiovascular disease. Patients with acute myocardial infarction have increased risks for depression, anxiety, psychosocial stress, or posttraumatic stress disorder. Together, these negative psychological factors when occurring after myocardial infarction have been referred to as postmyocardial psychological distress. Up to half of patients after myocardial infarction may experience some form of psychological distress, and this postmyocardial psychological distress has been associated with an increased risk of future cardiac events. Biologically plausible mechanisms by which postmyocardial psychological distress may lead to increased future cardiac risk include lesser physical activity, smoking (and failure to stop smoking), excess alcohol consumption, poor diet, obesity, inadequate sleep, inadequate social support, decreased medication adherence, and poor attendance at cardiac rehabilitation. The data on whether treatment of postmyocardial psychological distress improves cardiac prognosis are mixed and of variable quality, and further studies, particularly in patients with anxiety, stress, and posttraumatic stress disorder, would be helpful. Regardless, multiple interventions can reduce psychological distress and thus lead to improved psychological health, a greater sense of emotional well-being, and a better quality of life. A goal of health care professionals should be to treat not only the disease but also the person as a whole in front of us.

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Cite This Study

Levine et al. (2025) studied this question.

synapsesocial.com/papers/68d46fd431b076d99fa6a3b4https://doi.org/10.1161/cir.0000000000001381
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