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September 22, 2025Molecular Psychiatry0 citationsOpen Access

Lineage Specification of MUSE Stem Cells into Neural Phenotypes for Disease Modeling

Lineage specification into GABAergic, glutamatergic, dopaminergic, and astrocytic phenotypes using MUSE stem cells: a novel approach for modeling neurodegenerative and psychiatric disorders

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Authors

DADomenico AprileDPDeanira PatroneSSSura Hilal Ahmed Al Sammarraie

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Overview

Observational analysis demonstrates lineage specification of MUSE cells into neuronal phenotypes, suggesting new avenues for studying neurodegenerative disorders and psychiatric conditions.

Key Points

  • MUSE cells efficiently differentiate into GABAergic and glutamatergic neurons, enhancing disease modeling capabilities.
  • The study establishes protocols for neural progenitor differentiation, allowing exploration of lineage-specific dysfunctions.
  • Application of MUSE cells facilitates understanding of neurodegenerative disorders like Alzheimer’s and schizophrenia.
  • Investigating cellular mechanisms with MUSE models may lead to targeted therapies, reducing the use of animal models.

Cite This Study

Aprile et al. (2025) studied this question.

synapsesocial.com/papers/68d46fdc31b076d99fa6a566https://doi.org/10.1038/s41380-025-03251-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biological characteristics of Muse cells derived from MenSCs and their application in acute liver injury and intracerebral hemorrhage diseases2024 · 2 citations
  2. 2Stem Cell Therapy for Parkinson’s Disease: A Mechanistically Distinct Role for Muse Cells2026
  3. 3Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment2024 · 8 citations
  4. 4Human post-implantation blastocyst-like characteristics of Muse cells isolated from human umbilical cord2024
  5. 5MLC1 alteration in human iPSCs give rise to disease-like cellular vacuolation phenotype in the astrocyte lineage2026