Synthesis and antimicrobial activity of flavocillin ammonium salt

Flavocillin is a new beta lactam derivative of Penicillin where the R substituent is modified by a flavone group. Flavocillin ammonium salt was synthesized and tested in vitro on certain Gram + and negative bacteria for the purpose of this study. The activity of the flavocillin ammonium salt standard substance against S. aureus ATCC 6538 (1 µg/mL), S. epidermidis ATCC 12228 (8 µg/mL), M. catarrhalis ATCC 23245 (0,5 µg/mL), S. Mutans ATCC 25175 (0,5 µg/mL) and C. stiratum ATCC BAA 1293 (1 µg/mL) was determined. Interestingly the tested E. coli ATCC 8439 and S. aureus BAA44 were resistant to flavocillin. The results evidenced that Flavocillin mainly targeted the types of bacteria that infect the lungs and cause pneumonia, bronchitis and sepsis.