Pancreatic cystic tumors: literature review and early surgical outcomes at a certain center

Aim. To analyze the outcomes of patients with pancreatic cystic tumors managed at a high-volume hepato-pancreatobiliary (HPB) surgery center. Materials and Methods . Between 2014 and 2025, a total of 386 pancreatic resections were performed, with 82 (21.24%) for pancreatic cystic tumors. The mean patient age was 51 ± 10.7 years, and 63.4% of the patients were female. Results. Of the patients who underwent surgical operations, 10 (12.1%) had branch-duct intraductal papillary mucinous neoplasms (IPMNs), and 13 (15.88%) had main-duct IPMNs. Additionally, 25 patients (30.53%) were treated for mucinous cystic neoplasms, 1 (1.21%) for a cystic neuroendocrine tumor, 21 (25.63%) for solid pseudopapillary neoplasms, and 12 (14.63%) for serous cystadenomas. A retrospective pathohistological analysis of 121 cases of pancreatic head cancer following pancreatoduodenectomy revealed that 31 patients (25.61%) had developed adenocarcinoma associated with mucinous ductal neoplasms of various types. Conclusion. Pancreatic cystic tumors exhibit variable biological behaviors, necessitating differential diagnosis and management.