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Synapse
September 23, 2025

Computational Modeling of Network Topology and Molecular Dynamics for the Assessment of Therapeutic Potential of the Astragalus Membranaceus-Salvia Miltiorrhiza Drug Pair in the Treatment of Chronic Kidney and Heart Failure

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Authors

JLJiayou LiuJQJianguo Qin

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Overview

Bioinformatics analysis of the drug pair aims to elucidate molecular mechanisms, highlighting potential diagnostic targets in CKD and CHF.

Key Points

  • The study identifies 70 active ingredients and 158 common targets for the treatment of CKD and CHF.
  • Core targets include AKT1, STAT3, TP53, MAPK1, and RELA, with key regulatory pathways involving apoptosis and oxidative stress.
  • Molecular dynamics and docking analyses show strong stability and affinity of core ingredients with their targets.
  • Combining key targets enhances diagnostic accuracy for CKD and CHF, indicating strong clinical relevance and application.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d473a631b076d99fa6bee8https://doi.org/10.61882/ijkd.19.2.69
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