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September 23, 2025Cell Death and DifferentiationOpen Access

Induction of ferroptosis in prostate cancer by CCDC719-13 via TRIM21-mediated ubiquitination of SLC7A11

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Authors

BCBisheng ChengBeth Israel Deaconess Medical CenterQWQiong WangHuaihua UniversityZLZean LiEast China University of Science and Technology

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Implication

Experimental analysis shows CCDC719-13 induces ferroptosis by mediating SLC7A11 degradation via TRIM21, suggesting new therapeutic avenues.

Key Points

  • Inducing ferroptosis reduces tumor growth in prostate cancer, pointing to CCDC719-13 as a potential therapeutic target.
  • Overexpression of CCDC719-13 inhibits cell proliferation and apoptosis, confirming its role as a biomarker for poor prognosis.
  • Mechanistic studies show TRIM21-mediated ubiquitination of SLC7A11 is key to the ferroptosis triggered by CCDC719-13.
  • Recombinant CCDC7241aa enhances effectiveness of standard therapies like docetaxel and enzalutamide in advanced prostate cancer.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68d473b531b076d99fa6c557https://doi.org/10.1038/s41418-025-01580-x
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