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September 23, 2025International Journal of Molecular SciencesOpen Access

Multiplexed Quantitation of Plasma Proteins by Targeted Mass Spectrometry for Early Diagnosis of Pancreatic Ductal Adenocarcinoma

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Authors

DKD. KorobkovIMIvan MolodtsovАКА. С. Кононихин

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Overview

Quantitative analysis of plasma proteins identifies potential biomarkers for pancreatic cancer, suggesting early detection strategies.

Key Points

  • A model based on six plasma proteins distinguishes early-stage pancreatic ductal adenocarcinoma with an accuracy of 90%.
  • Among 132 participants, differential levels of proteins were identified in patients with pancreatic cancer versus healthy controls.
  • Multiple reaction monitoring mass spectrometry accurately quantified plasma proteins to assess potential biomarkers for pancreatic cancer.
  • Findings highlight the urgency for improved early diagnosis methods to enhance survival rates in pancreatic cancer patients.

Cite This Study

Korobkov et al. (2025) studied this question.

synapsesocial.com/papers/68d473b531b076d99fa6c684https://doi.org/10.3390/ijms26189219
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