Mechanoradical-Driven C-H Halogenation and Nitration of Arenes and Vicinal Dibromination of Alkenes in the Solid-State

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This is a Experimental Study study.

Yunfeng Jiang; Xiang Gu; Taoyong Wang; KaKing Yan

doi:10.1039/d5mr00094g

January 1, 2025RSC MechanochemistryOpen Access

Mechanoradical-Driven C-H Halogenation and Nitration of Arenes and Vicinal Dibromination of Alkenes in the Solid-State

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Key Points

A solvent-free mechanochemical approach enables effective C–H halogenation and nitration of arenes.
In-situ-generated mechanoradicals oxidize halide or nitrite salts, facilitating radical reactions.
The methodology showcases solid-state reactions for efficient functionalization of organic compounds.
This approach highlights the potential of mechanochemistry for green and sustainable synthetic processes.

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Implication

This mechanochemical method facilitates C–H halogenation and nitration in arenes, implying efficiency in radical reactions.

Abstract

We report a solvent-free mechanochemical approach for the C–H halogenation and nitration of arenes. In-situ-generated oxygen-centered mechanoradicals readily oxidize halide or nitrite salts, enabling C–H functionalization of arenes. Radical trapping...

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Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68d4759931b076d99fa6d9d0 https://doi.org/10.1039/d5mr00094g

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Mechanoradical-Driven C-H Halogenation and Nitration of Arenes and Vicinal Dibromination of Alkenes in the Solid-State

Key Points

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Implication

Abstract

Discussion

Cite This Study

Mechanoradical-Driven C-H Halogenation and Nitration of Arenes and Vicinal Dibromination of Alkenes in the Solid-State

Key Points

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Implication

Abstract

Discussion

Cite This Study

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