This research reports an innovative 5-exo cyclization approach using terpenes in gold(I)-catalyzed reactions, suggesting new avenues in reactivity.
Natural terpene-derived substrates have been used as stereochemical templates in the gold(I)-catalyzed cycloisomerization of aliphatic 1-bromoalkynes. The conformational restrictions imposed by these substrates have unlocked an unprecedented 5-exo cyclization mode in gold catalysis. This reactivity was extended to structurally simplified substrates.
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Arto et al. (2025) studied this question.
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