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Exploring Organ-on-Chip Systems as Functional Bioassays for Drug Screening: Principles and Models

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This review highlights how organ-on-chip systems emulate organ function for drug screening, suggesting enhanced predictive pharmacology.

Organ-on-chip systems mimic human organ functions, providing realistic conditions for drug testing.
These systems utilize microfluidic techniques to connect organ chips, improving pharmacokinetics modeling.
While challenges remain in scaling and cell sourcing, organ-on-chip technologies promise personalized preclinical testing.
They may significantly improve the relevancy and efficiency of pharmacological evaluations related to human conditions.

Dong Yu Zhu (2025) studied this question.

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View Full Paper

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Authors

This review highlights how organ-on-chip systems emulate organ function for drug screening, suggesting enhanced predictive pharmacology.

Organ-on-chip systems mimic human organ functions, providing realistic conditions for drug testing.
These systems utilize microfluidic techniques to connect organ chips, improving pharmacokinetics modeling.
While challenges remain in scaling and cell sourcing, organ-on-chip technologies promise personalized preclinical testing.
They may significantly improve the relevancy and efficiency of pharmacological evaluations related to human conditions.

Dong Yu Zhu (2025) studied this question.

View Full Paper

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