Case report demonstrates the efficacy of beta blockers and sirolimus in treating rare neonatal hemangiomatosis, indicating a new treatment pathway.
Infantile hemangiomas are common, but diffuse neonatal hemangiomatosis is rare. The first-line treatment for infantile hemangiomas is enteral propranolol. However, optimal treatment for diffuse neonatal hemangiomatosis remains unknown. We describe the case of a now 24-month-old child with diffuse, innumerable cutaneous and hepatic infantile hemangiomas who was treated with beta blockers and sirolimus therapy in the setting of congestive heart failure and pulmonary hypertension as a neonate. The purpose of this paper is to demonstrate our experience with the use of sirolimus in combination with beta blockers for life-threatening diffuse hemangiomatosis. It highlights the role of intravenous beta blockers when oral propranolol could not be used due to clinical complications.
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Cappello et al. (2025) studied this question.
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