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This is a Quantitative Study study (also classified as: Experimental Study).

September 24, 2025Open Access

An atlas of natural killer cell receptor expression on healthy donor T and NK lymphocytes

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This analysis reveals receptor co-expression patterns in T and NK cells, indicating diversity across donor sex and maturation stages.

NK cells demonstrate universal expression of CD45RA and CD161, alongside inhibitory receptors like TIGIT and TIM3.
Up to 50% of NK cells express CD8, which correlates with increased cytotoxicity compared to CD8- NK cell populations.
CD8+ T cells show enhanced expression of NK-associated receptors such as NKG2A and CD16 as they differentiate.
The use of a 25-colour flow cytometry panel allowed for comprehensive assessment of receptor expression and functionality.

Lee et al. (2025) studied this question.

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September 24, 2025Open Access

View Full Paper

Ask AI

Bookmark

Authors

This analysis reveals receptor co-expression patterns in T and NK cells, indicating diversity across donor sex and maturation stages.

NK cells demonstrate universal expression of CD45RA and CD161, alongside inhibitory receptors like TIGIT and TIM3.
Up to 50% of NK cells express CD8, which correlates with increased cytotoxicity compared to CD8- NK cell populations.
CD8+ T cells show enhanced expression of NK-associated receptors such as NKG2A and CD16 as they differentiate.
The use of a 25-colour flow cytometry panel allowed for comprehensive assessment of receptor expression and functionality.

Lee et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark