Mendelian randomization combined with single-cell sequencing analysis revealed prognostic genes related to myeloid cell differentiation in prostate cancer and experimental verification
This research demonstrates prognostic gene identification in prostate cancer via single-cell sequencing and mendelian randomization, suggesting implications for drug development.
Key Points
Five prognostic genes were identified through mendelian randomization and risk modeling of prostate cancer.
The analysis revealed that the high risk group showed a lower survival rate compared to the low risk group.
Single-cell sequencing analysis confirmed the expression of prognostic genes in key cells, emphasizing their roles.
The study established a nomogram that effectively predicts the survival status of prostate cancer patients.