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September 27, 2025Safety and Risk of PharmacotherapyOpen Access

The Safety of the Use of Antidepressants: Analysis of the Russian Database of Spontaneous Reports

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Authors

YGYu. М. GomonVLV. A. LavrovaАКА. С. Колбин

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Overview

Observational analysis revealed significant adverse drug reactions in antidepressants, pointing to a need for further research.

Key Points

  • Significant adverse drug reactions associated with antidepressants like vortioxetine and sertraline were observed, indicating safety concerns.
  • Amitriptyline had the highest number of reports for adverse reactions, with 470 cases reported, while imipramine had only 2.
  • Statistically significant associations were found between selective serotonin reuptake inhibitors and various disorders, including gastrointestinal and endocrine issues.
  • Continued underreporting of adverse drug reactions highlights the need for further studies to clarify the safety profiles of commonly used antidepressants.

Cite This Study

Gomon et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3ddeebfec0fc523683fhttps://doi.org/10.30895/2312-7821-2025-521
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety of antidepressants commonly used in 6–17-year-old children and adolescents: A disproportionality analysis from 2014–2023 on the basis of the FAERS database2025 · 5 citations
  2. 2Analysis of Antidepressant-Related Adverse Events in National and International Literature: A Scoping Review2026
  3. 3Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor use and sexual dysfunction: a pharmacovigilance analysis2026
  4. 4Pharmacovigilance of SSRIs in Children and Adolescents withDepression: Disproportionality Analysis of Serotonin Adverse EventsUsing the FAERS Database2026
  5. 5Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database2018 · 108 citations