This research demonstrates CO releasing molecules (CORMs) improving in situ reactions, highlighting their role in palladium-catalyzed aminocarbonylations.
We report the adoption of a two-chamber reactor making use of aliphatic aldehydes in the role of CO releasing molecules (CORMs). Upon photocatalytic conditions, an acyl radical (RCO•) was first formed, prone to lose CO. The resulting alkyl radical was employed in the in situ conjugate addition onto a Michael acceptor (in the first chamber), and the released CO was employed in ex situ palladium-catalyzed aminocarbonylations (in the second chamber) to ensure a 100% atom-economical reaction.
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Cassera et al. (2025) studied this question.
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