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September 27, 2025PharmaceuticalsOpen Access

Pregabalin and Duloxetine in Patients with Non-Nociceptive Pain: A Narrative Review Exploring the Pharmacological Effects of This Combination

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Authors

GMGianmarco MarcianòMEMaurizio EvangelistaCVCristina Vocca

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Overview

Narrative review explores the efficacy and safety of combination therapy for neuropathic and nociplastic pain.

Key Points

  • Combination therapy of pregabalin and duloxetine shows synergistic effects in managing non-nociceptive pain, and reduces adverse events.
  • Evidence indicates that combination therapy is generally not inferior to monotherapy, with variations in safety outcomes observed.
  • Patients experiencing side effects from higher doses may benefit from lesser dosages through combination therapy strategies.
  • Combination therapy may offer relief for those with central neuropathic pain and mental health conditions like anxiety–depression.

Cite This Study

Marcianò et al. (2025) studied this question.

synapsesocial.com/papers/68d7be5eeebfec0fc523754fhttps://doi.org/10.3390/ph18101434
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