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September 27, 2025Open Access

Interferometric Image Scanning Microscopy for label-free imaging at 120 nm resolution inside live cells

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Authors

MKMichelle KüppersWMW. E. Moerner

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Overview

Novel imaging technique achieves 120 nm resolution and enhances contrast in live cells, suggesting improved biological insight.

Key Points

  • The iISM technique allows label-free imaging of live cells, achieving about 120 nm resolution while minimizing photodamage.
  • High signal-to-noise ratio supports the detailed visualization of intracellular organelles within live specimens.
  • By combining iISM with confocal fluorescence microscopy, researchers can correlate dynamic processes with molecular specificity.
  • This advancement opens new opportunities for studying complex biological interactions and processes in near-native conditions.

Cite This Study

Küppers et al. (2025) studied this question.

synapsesocial.com/papers/68d7cc66eebfec0fc523888ehttps://doi.org/10.1101/2025.09.19.677416
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