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This is a Experimental Study study.

Cell-Penetrating Peptide-engineered Solid Lipid Nanoparticles for Enhanced Endocytotic Internalization and Transdermal Penetration

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This research shows enhanced endocytosis and transdermal penetration in keratinocytes, suggesting innovative drug delivery applications.

Solid lipid nanoparticles engineered with Laminin-332 significantly improve transdermal penetration.
Binding kinetics with α3β1 integrin correlate with peptide density, confirming a specific interaction mechanism.
Lipid raft-mediated endocytosis is the main pathway for uptake, showing that this method effectively penetrates skin barriers.
Ex vivo results indicate concentration-dependent cargo delivery is enhanced via receptor-targeted surface engineering.

Kang et al. (2025) studied this question.

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