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September 27, 2025Cell Communication and SignalingOpen Access

Aberrant neuronal firing: a paracrine route to glioblastoma expansion

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Authors

JLJi Yeon LeeBKBon Il KooTLTrang Huyen Le-Kim

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Overview

Experimental analysis reveals neuronal hyperstimulation contributes to glioblastoma recurrence, suggesting paracrine signaling's role.

Key Points

  • Neuronal hyperstimulation leads to glioblastoma regrowth after chemotherapy, emphasizing the danger of its microenvironment.
  • Application of power-frequency electric fields invokes abnormal neuronal activity, confirmed by calcium influx and neurotransmitter release.
  • Co-culture systems highlight the significant impact of paracrine signaling on glioblastoma cell proliferation post-chemotherapy.
  • Blocking glutamate release from neurons significantly reduces glioblastoma cell growth, indicating potential therapeutic strategies.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68d7e84439bbb06045426d0fhttps://doi.org/10.1186/s12964-025-02404-8
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