C1 esterase inhibitor treatment improved blood-brain barrier function in hypoxic neonatal mice, suggesting implications for vascular stability.
Background/Purpose: Hypoxia-Ischemia (HI) adversely affects blood–brain barrier (BBB) function. In neonatal hypoxic mice, C1 esterase inhibitor (C1-INH) treatment abolished BBB damage and brain oedema, but the underlying mechanism is unknown. We hypothesized that C1-INH affects the metabolism of phospholipids, playing a major role in vascular and BBB stability.
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Jung et al. (2025) studied this question.
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