Case report details a symmetrical adverse reaction in an 88-year-old woman, suggesting caution with dual beta-lactam therapy.
This report highlights a rare case where an 88-year-old woman developed symmetrical drug-related intertriginous and flexural exanthema, induced by concomitant treatment with intravenous injections of two beta-lactam antibiotics, namely ceftriaxone and piperacillin–tazobactam. This case emphasizes the importance of minimizing dual beta-lactam usage and on the need for early detection and management of this rare adverse drug reaction.
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Mathews et al. (2025) studied this question.
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