Analysis of a novel platform enhances biosafety and flow cytometry in infectious disease research.
Introduction: Flow cytometry remains one of the most central technologies with broad applications in immunology and infectious disease research. In the lack of compatible measures for pathogen inactivation, cytometric analysis of live cells derived from infectious samples classically poses exposure risks to both operators and environment. Enclosing a cell analyzer in a biosafety cabinet (BSC) could significantly improve safety margins for laboratory operations but has unknown impacts on instrument performance. Here, we describe and characterize the performance of a novel, BSC-housed analyzer for cytometric analysis of infectious samples within a biosafety level-3 laboratory.
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Cohen et al. (2025) studied this question.
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