Exploration of NLRX1's involvement in mitophagy dysfunction in Alzheimer's Disease, suggesting new therapeutic targets.
Background Mitophagy dysfunction in Alzheimer's Disease (AD) accelerates disease progression, highlighting the need for novel therapeutic targets. Although Nucleotide oligomerization domain – like receptor X1 (NLRX1) regulates mitophagy, its role in AD remains unclear. This study aimed to elucidate NLRX1's function in AD – associated mitophagy and its therapeutic potential.
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Qiu et al. (2025) studied this question.
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