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September 29, 2025Cancer Research

Abstract A027: HuR drives immune evasion, metastases and KRAS addiction in pancreatic ductal adenocarcinoma: implications for IO-based and KRAS inhibitor therapies

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Authors

MGM. GuoNorthwest Minzu UniversityJFJennifer M. FinanOregon Health & Science UniversityHHHen HalamishOregon Health & Science University

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Implication

Research demonstrates HuR's involvement in immune evasion and KRAS signaling in pancreatic ductal adenocarcinoma, suggesting new therapeutic strategies.

Key Points

  • HuR expression promotes immune evasion, leading to slower tumor growth in pancreatic ductal adenocarcinoma models.
  • HuR-WT tumors show significantly less T cell infiltration and greater endothelial cell infiltration than HuR-KO tumors.
  • Inhibition of mTOR activity in HuR-WT cells enhanced T cell function in co-culture, indicating HuR's role in immune regulation.
  • HuR-KO tumors exhibit greater resistance to KRAS inhibitors, underscoring HuR's link to KRAS addiction and tumor progression.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68da58e0c1728099cfd1182ehttps://doi.org/10.1158/1538-7445.pancreatic25-a027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 5357: The tumor-intrinsic RNA binding protein HuR is essential for anti-tumor immunity in PDAC2024
  2. 2The Role of Tumor-Intrinsic HuR in Modeling the Pancreatic Tumor Microenvironment: Molecular Mechanisms and Therapeutic Opportunities2025 · 3 citations
  3. 3Data from HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer2025
  4. 4Abstract 1586: Unraveling the importance of pancreatic cancer extracellular signaling to endothelial cells within the tumor microenvironment2024
  5. 5HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer2025 · 3 citations