Experimental analysis demonstrated that high pressure stabilizes L-cysteine SAMs on gold electrodes, while high temperatures induce destabilization.
Self assembled monolayer films (SAMs) made of L-cysteine molecules as components deserve much credit, thanks to their natural biocompatibility and ability of attainment multiple charged and conformational states triggered by changes of external conditions. Here we present the new experimental results about an impact of high pressure and temperature on the L-cysteine-modified gold electrodes based on the kinetic patterns for two freely diffusing redox probes, viz., [Fe(CN)6]3−/4− and [Ru(NH3)6]3+/2+ involved in electron exchange with L-cysteine/Au electrodes. We demonstrated that there is an almost reversible changeover in the both system's performance ascribable to switchable configuration of L-cysteine self-assembled films on Au electrodes under pressure, seemingly accompanied by the film squeezing and stabilization by the pressure up to 150 MPa. On the contrary, Au/L-cysteine films exhibited destabilization at elevated temperatures above 30 °C.
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Dolidze et al. (2025) studied this question.
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