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Multiple sclerosis (MS) continues to challenge clinicians and researchers alike with its non-specific and heterogeneous presentation and unpredictable course. Among its earliest and most presenting features is visual dysfunction—commonly optic neuritis—which not only reflects localized optic nerve inflammation but also serves as a harbinger of widespread central nervous system (CNS) pathology. This intimate relationship between vision and neurodegeneration positions the eye as a functional and structural biomarker of MS. Yet, for too long, neurology and ophthalmology have operated in parallel rather than in concert.
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Chandra et al. (2025) studied this question.
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