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September 30, 2025BiomedicinesOpen Access

Distinctive Gene Expression Profiles and Biological Responses of Skin Fibroblasts to Nicotinamide Mononucleotide: Implications for Longevity Effects on Skin

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Authors

SKS.S. KangJPJi-Won ParkECEunbyul Cho

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Overview

In vitro analysis reveals that nicotinamide mononucleotide enhances fibroblast function and reduces aging effects, indicating potential for skin treatments.

Key Points

  • Nicotinamide mononucleotide significantly improves NAD+ levels and reduces skin aging effects.
  • Distinct gene expression profiles show NMN's unique role in cytokine activity compared to other precursors.
  • In vitro analyses demonstrate enhanced fibroblast function, including improved mitochondrial efficacy and increased cell proliferation.
  • The findings lay the groundwork for further NMN-based therapeutic applications in dermatology.

Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e308a7d58c25ebb12ebhttps://doi.org/10.3390/biomedicines13102395
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