Anxiety and depression are complex neurological disorders that are considered by WHO to be among the most severe health problems. The causes of depression and anxiety disorders are an imbalance between oxidants and antioxidants in favour of the oxidants, resulting in a disruption of redox signalling and control and molecular damage. Banana peels can increase the antioxidants to counteract free radicals. This study explored the effectiveness of several roasted Agung banana peel extract doses, namely 200, 400, and 800 mg/kg b.w., as anxiolytics and antidepressants. The 400 mg/kg b.w. RBPE showed the most consistent anxiolytic and antidepressant effects among the other doses. Due to the roasting process, this pharmacological effect is thought to be caused by the emergence of a new flavonoid compound, morin. Increasing the dose to 800 mg/kg did not cause an increase in pharmacological effects, presumably due to a ceiling effect.
Hadisoewignyo et al. (2025) studied this question.