Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 30, 2025Open Access

Bayesian inference of tissue-migration histories in metastatic cancer from cell-lineage tracing data

View Full Paper
Ask AI
Bookmark
Share

Authors

SSStephen J. StaklinskiASArmin SchebenLBLise M. Brault

Discussion

Loading...

Member takes

Overview

Probabilistic modeling reveals tissue migration patterns in metastatic cancer, suggesting distinct migration modes across clones.

Key Points

  • BEAM infers complex tissue migration histories in metastatic cancer, improving upon traditional methods.
  • Using simulated data, BEAM reliably outperformed existing algorithms in inferring tissue migration graphs.
  • Public data analysis showed distinct migration modes in lung and prostate cancer clones, with reseeding of tumors.
  • This framework offers insights into the timing and directionality of tissue migration in various cancer types.

Cite This Study

Staklinski et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e358a7d58c25ebb18dbhttps://doi.org/10.1101/2025.09.09.668633
View Full Paper
Ask AI
Bookmark
Share