Research reveals phenothiazine derivatives suppress free-radical oxidation in isopropyl alcohol, suggesting mechanisms for antioxidant action.
A series of biologically active phenothiazine derivatives were studied as inhibitors of the free‐radical chain oxidation of isopropyl alcohol by atmospheric oxygen. It was found that these compounds exhibit antioxidant properties, effectively suppressing the oxidation process. The key rate constants quantitatively characterizing the efficiency of their antioxidant action were determined. Mathematical modeling was used to analyze the proposed oxidation mechanism, identifying the critical stages that determine the inhibitory efficacy of phenothiazines. It was shown that the inhibitor regeneration reaction plays a significant role, leading to a high inhibition capacity. The application of mathematical modeling allowed the proposal of an oxidation mechanism that provides a comprehensive explanation for all currently available experimental and literature data.
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Sharaeva et al. (2025) studied this question.
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