Unveiling the silent struggles: The interplay of stress, depression, and biophysiological responses in cancer patients

BACKGROUND: Stress and depression are prevalent among cancer patients and have negative impacts on their overall health. This study investigates the prevalence of stress and depression among cancer patients and examines their relationship with biophysiological variables. MATERIAL AND METHODS: This descriptive cross-sectional study included 148 cancer patients undergoing radiation therapy conducted in the year 2024. Depression and stress were assessed using standardized scales, while biophysiological parameters—including heart rate, respiration rate, blood pressure, and salivary amylase—were monitored. Relationships between physiological and psychological variables were analyzed using Spearman’s rank correlation. The study employed both descriptive and inferential statistical analyses. Descriptive statistics included frequency, percentage, mean, and standard deviation, while inferential analysis used Spearman’s rank correlation to assess relationships between biophysiological parameters and psychological variables, with significance set at P < 0.05. RESULTS: Stress levels were significantly high, with 60.4% experiencing very high stress and 80.4% reporting extreme stress. Additionally, 62% of participants exhibited moderate to severe depression. A significant positive correlation was observed between depression and heart rate ( P = 0.005) as well as respiration rate ( P = 0.023). However, stress did not show a significant impact on biophysiological parameters. CONCLUSION: The correlation between depression and increased heart rate and respiration underscores the need for integrated psychological support in cancer treatment. Future research should explore additional biomarkers and evaluate the efficacy of psychological interventions in mitigating stress and depression.