TPP-coated Mo-doped W₁₈O₄₉ biodegradable nanomaterials with mitochondria-targeting and pH-responsive properties for synergistic photothermal therapy/chemodynamic therapy/chemotherapy

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Key Points

The biodegradable TPP-coated Mo-doped W18O49 nanomaterials improve treatment effectiveness against tumors by utilizing multiple therapy modes.
Notable effects include targeted delivery, where mitochondria-targeting significantly enhances photothermal therapy and chemotherapy outcomes.
This study utilized a unique fabrication process for developing these advanced nanomaterials with specific targeting capabilities.
These findings highlight promising implications for cancer therapies, especially the combination of chemotherapies and physical treatment strategies.

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Investigative nanomaterials exhibit mitochondria-targeting and pH-responsive properties, indicating enhanced cancer treatment efficacy.

Schematic illustration of the fabrication process of TMoWODC and its antitumor mechanism.

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Ren et al. (2025) studied this question.

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