Analysis demonstrates quantification of rotenone using solid phase extraction in rat plasma, suggesting its efficacy in drug monitoring.
Pharmacokinetics studies rely on different quantitative methods to determine the effect of the drugs on organisms and to assess their safety and efficiency. Although rotenone is known to be toxic against non-target cells, it possesses anti-cancer properties that can make it a potential drug candidate upon structure modification. An ultra-high-performance liquid chromatography method for the quantification of rotenone was developed and validated. The rotenone in rat plasma samples was extracted by a solid phase extraction method and rotenone was identified in ppb levels. The developed method was found to be simple, rapid, accurate, and precise and can be used for routine therapeutic drug monitoring. The method presented in this study can be used as the reference chromatographic conditions for further studies on the routine drug monitoring of structurally modified rotenone derivatives.
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Caleja-Ballesteros et al. (2025) studied this question.
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