This method demonstrates effective cyanation and alkynylation of allylic gem-difluorides, indicating a novel approach in organic synthesis.
Wereport a palladium-catalyzed, Hiyama-type defluorinative cross-coupling of allylic gem-difluorides with trimethylsilyl cyanide and silylalkynes via selective C-F bond activation. The transformation proceeds through a tandem sequence of oxidative addition, Si-F-assisted...
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Miao et al. (2025) studied this question.
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