Experimental data shows hsa_circRNA_0101125 boosts cell migration and invasion in esophageal squamous cell carcinoma, suggesting critical roles for miR-143-3p and ZNF148.
Key Points
Hsa_circRNA_0101125 promotes proliferation, migration, and invasion of esophageal squamous cell carcinoma cells.
Inhibition of hsa_circRNA_0101125 reduced cell viability, migration, and invasion while altering expression of ZNF148 and miR-143-3p.
The relationship between hsa_circRNA_0101125, miR-143-3p, and ZNF148 was confirmed through dual-luciferase assays and expression measurement techniques.
Findings support the idea that hsa_circRNA_0101125 acts through miR-143-3p to influence cancer cell behavior, highlighting potential therapeutic targets.