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Interrupted time series analysis showed silencing penicillin alerts minimally increased cefazolin use, suggesting limited impact on prescribing practices.
We evaluated the impact of silencing penicillin cross-reactivity alerts on perioperative antibiotic prescribing and surgical site infections (SSIs) in 6 hospitals using an interrupted time series analysis. Silencing the alerts minimally increased cefazolin prescribing among penicillin allergy labeled patients (sensitivity analysis only; P = 0.03) and had no influence on SSIs (P = 0.32).
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Durkin et al. (2025) studied this question.
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