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This is a Experimental Study study.

October 1, 2025

2D and 3D Differentiation of Human Mammary Basal Cells Long-Term Expanded in YDAC-Supplemented F Medium.

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Human mammary basal cells undergo synchronized differentiation after YDAC withdrawal, promoting diverse epithelial lineages.
Expanded cells maintained basal identity in a 2D culture system and transitioned to bilayered 3D structures with prolonged exposure to YDAC.
The study utilized a defined chemical cocktail to enhance cell growth and survival in F medium, providing significant insights into epithelial biology.
This scalable protocol may enable new possibilities for organoid modeling and functional studies of mammary tissue.

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This study demonstrates 2D and 3D differentiation of human mammary basal cells, indicating YDAC’s role in lineage specification.

Akihito Inoko (2025) studied this question.

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